PARA CRIADERO MIRABEL Y JUAN F76 MIREN ESTE ABSTRACT BIEN INTERESANTE
Abstract
Journal of the American Veterinary Medical Association
May 1, 2010, Vol. 236, No. 9, Pages 983-990
doi: 10.2460/javma.236.9.983
Physical and clinicopathologic findings in foals derived by use of somatic cell nuclear transfer: 14 cases (2004–2008)
Aime K. Johnson, DVM, DACT; Stuart C. Clark-Price, DVM, MS, DACVIM, DACVA; Young-Ho Choi, DVM, PhD; David L. Hartman, DVM; Katrin Hinrichs, DVM, PhD, DACT
Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843. (Johnson); Performance Equine Associates, 15257 Hwy 377, Whitesboro, TX 76273. (Clark-Price, Hartman); Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843. (Choi); Departments of Large Animal Clinical Sciences and Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843. (Hinrichs)
Dr. Johnson's present address is the JT Vaughn Large Animal Teaching Hospital, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.
Dr. Clark-Price's present address is the Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802.
Dr. Hartman's present address is Hartman Equine Reproduction Center, 15225 Hwy 377, Whitesboro, TX 76273.
Supported by the Link Equine Research Endowment Fund at Texas A&M University and Cryozootech S.A.
The authors thank Jennifer Pirkle for technical assistance.
Address correspondence to Dr. Johnson (akj0001@auburn.edu).
Objective—To describe the health status of foals derived by use of somatic cell nuclear transfer (NT) at a university laboratory.
Design—Retrospective case series.
Animals—14 live-born NT-derived foals.
Procedures—Medical records from 2004 through 2008 were evaluated to identify all pregnancies resulting in live-born NT-derived foals. Information obtained included gestation length, birth weight, foaling complications, gross abnormalities of the fetal membranes, appearance of the umbilicus, mentation of the foal, limb deformities, and any other abnormalities detected in the neonatal period. Clinicopathologic data were also evaluated when available. Records of 4 recipient mares during gestation were included.
Results—Six foals were clinically normal for all evaluated variables. The most common abnormalities detected in the remaining 8 foals included maladjustment, enlarged umbilical remnant, and angular deformity of the forelimbs. Two foals died within 7 days after parturition; in the remaining foals, these conditions all resolved with medical or surgical management. Large offspring syndrome and gross abnormalities of the fetal membranes were not detected. The 12 surviving foals remained healthy.
Conclusions and Clinical Relevance—Associated problems of calves resulting from use of NT have been reported, but there are few data on the outcome of foals resulting from adult somatic cell NT in horses. Although this population of foals had a lower perinatal mortality rate than has been reported for NT-derived calves, some NT-derived foals required aggressive supportive care. Birth of foals derived from NT should take place at a center equipped to handle critical care of neonates.
